Itraconazole  - MIC-distributions of clinical strains and reference strains.

    Susceptible Indeterminate Resistant
 MIC (mg/L)   <.032 .064 .125 .25 .5 1 2 4 8 >8
C.albicans   86 75 46 6 1 2 - - - 3
C.glabrata   1 1 1 2 7 12 14 5 8 18
C.parapsilosis   1 4 5 15 7 1 - - - -
C.tropicalis   - 1 5 6 2 1 - - - -
C.lusitaniae   - 1 3 1 - - - - - -
C.krusei   - - 1 - 6 4 - 1 - -
                       
C.parapsilosis_ATCC_22019

0.06-02.5

  5 17 20 3          
C.krusei ATCC 6258

0.125-0.5

  2 30** 12 5          

Boxes with blue colour: results from several international studies. Numbers in boxes are test results on clinical strains in laboratories represented on the subcommittee for AFST. 

*Repeated internal QC with ATCC-strains with NCCLS recommended ranges (also marked in red colour) and the distribution of test results from several laboratories. 

**Data skewed since not all determinations were performed with a full range of dilutions

 

 

NRMM, 2004-03-19